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These conserved residues are necessary but not sufficient for the ketosteroid isomerase activity

In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione

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Platform crossing frequency further demonstrated spatial memory deficits in VPA-exposed rats, which showed significantly fewer crossings compared to controls ( P 0.05 )