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The vast majority of animal studies are conducted without considering biological variables such as age, sex, and comorbidities, including hypertension, diabetes, and metabolic syndrome

This happens, for example, when the gastrointestinal system is compromised by conditions such as dysbiosis , malabsorption o increased intestinal permeability In these situations, nutrients do not reach the tissues optimally

The reduced form of doxorubicin, resulting from AKR1C3 activity, exhibits lower affinity and capacity to bind to DNA (Heibein et al., 2012)

Imidazoline (I Clonidine is an imidazoline derivative that binds to central imidazoline I 1 ) Receptor Agonism: 1 receptors in the brainstem (including the nucleus tractus solitarii and rostral ventrolateral medulla) with high affinity