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A standard weight-management titration reference (based on FDA-approved Wegovy protocol): Weeks 14: 0.25 mg once weekly Weeks 58: 0.5 mg once weekly Weeks 912: 1.0 mg once weekly Weeks 1316: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance for obesity) For T2DM glycemic control, lower maintenance doses (0.52.0 mg weekly) are used per Ozempic labeling

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Finally, the relative abundance of sequences that could not be assigned to a defined genus was significantly higher in vehicle- and 5A-1MQ-treated mice switched from WD to LD relative to the WD control group (the former before FDR correction only