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Even when a peptide drug has one intended recipient, we dont always know who else is in the chat receiving the message

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

doi: 10.1089/ars.2012.4603

Thus, it seems reasonable to conclude that any of these alternate explanations cannot entirely account for the hypodipsic effects following GLP-1R activation