Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway
Under the same experimental format as Figure 1e left column, except using a molar ratio of GSSSG and LASSS to HGF (1:8000), LASSS-treated HGF (Figure 1e right column, bar 9 ) displayed about 2-fold higher c-met binding than the control HGF level ( bar 8 , in which HGF just received the solvent) equivalent to the positive controls ( bars 2 and 2 in the left column)
Analyst 2012 ,137, 22852296
Key ingredients include L-Glutathione, N-Acetyl Cysteine (NAC), Vitamin C, and Rosehips, among others