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Description

A "significant reduction'^ in terms of the present application is defined as a reproducible reduction (in VEGF binding to VEGFR2) of at least about 50%, about 55%, about 60% or ' about 65% at any amount between about 100 fold and about 1000 fold (e.g., about 500 fold or about 750 fold) molar excess of antibody over VEGF

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A 5-minute habituation period was followed by the gentle placement of a food pellet (choices included chow or high-sucrose or high-fat content) in the center of the box

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