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Non-Incretin Pathways While incretin-based drugs have dominated recent advances in obesity care, a growing number of biotechs are pursuing non-incretin pathways that aim to go beyond appetite suppression focusing instead on improving metabolic health, preserving muscle mass, and enhancing body composition

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(Research has identified mast cells as one of the immune cell types involved in the inflammatory cascades that influence arterial plaque development and lipid-related cardiovascular risk, as I note in my MCAS info page.) In neurological disease , research in animal models of stroke and vascular dementia has shown that GLP-1RAs reduce both microglial activation and neuroinflammation, leading to better protection of the brain from injury and cognitive deterioration