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Any new or worsening symptom, particularly severe abdominal pain, persistent vomiting, yellowing of the skin or eyes, or signs of allergic reaction, requires prompt medical attention

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The clinical expert consulted by CADTH nevertheless remarked that a height velocity of at least 2 cm per year (or 1 cm per 6 months) is generally considered sufficient to continue mecasermin treatment, by analogy with the clinical practice in patients treated with GH for GH deficiency

Uccellatore A, Genovese S, Dicembrini I, et al