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2.4 Interventions 2.4.1 Exercise Program A detailed exercise protocol, in accordance with the CERT reporting checklist, is available in the Methods D of the Electronic Supplementary Material (ESM) in the primary trial report [29], including specific examples of exercise programs

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Up-regulation of mGlu2 receptors was observed in cultured DRG neurons isolated from 30-day acetyl-l-carnitine-treated -GalA knockout mice, which was no longer detectable in DRG neurons isolated 30 days after the end of treatment, hinting at an additional mechanism being responsible for the long-term analgesic effect [35]

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