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Description

Co-administration of topiramate with diltiazem hydrochloride extended-release resulted in a 16% increase in C max and a 19% increase in AUC 12 of topiramate

One-compartment and two-compartment models were investigated, confirming the suitability of a two-compartment disposition structure (Delta OFV, approximately 8000 points)

For a 200 lb person, that is approximately 6 to 8 pounds

But this effect, if it exists, appears to be minimal and might be offset by the higher trough levels providing more consistent appetite control in the back half of each three-to-four day cycle