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57 Furthermore, a subsequent prespecified analysis of the trial examined the effects of semaglutide in patients with and without history of HF at enrolment, with a significant reduction in MACE in patients with HFrEF and HFpEF and a 21% and 25% reduction in the HF composite endpoint, respectively

doi: 10.3389/fendo.2021.721135 14 DruckerDJ

Finally, evaluation of small molecule GLP-1R agonists beyond their effectiveness in T2DM and obesity presents a significant area of opportunity

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