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Some studies describe the use of massive phenobarbital infusions (analogous to pentobarbital)

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If you typically inject on Sunday mornings, your last tirzepatide would be Sunday and your first semaglutide would be the following Sunday

The GLIDE trial showed the worsening effect of HbA1c and weight after cessation of therapy, and it would have been of interest to determine the longer-term impact of GLP-1 therapy beyond 6 months