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Federal law generally bars compounders from making copies of FDA-approved drugs, but sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act allow compounding under certain circumstances, including during shortages

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These findings reveal that HSC aging is a driver of aging-associated inflammation through maladaptive trained immunity and broaden the possible clinical applications of targeting HSCs from hematological diseases to include countering aging-associated physiological decline and improving healthspan