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MLN2238 (Ixazomib) Ixazomib (MLN2238) inhibe el sitio proteoltico tipo quimotripsina (5) del 20S proteasome con IC50 y K i de 3,4 nM y 0,93 nM en ensayos sin clulas, respectivamente, tambin inhibe los sitios proteolticos tipo caspasa (1) y tipo tripsina (2), con IC50 de 31 y 3500 nM