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The right choice depends on individual circumstances, priorities, risk tolerance, and practical constraints

Preclinical studies indicate that these drugs shift macrophage polarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype through HIF-1 downregulation and AMPK activation, enhancing tissue repair and reducing oxidative stress (95, 96)

In 2021 and 2022, Pfizer $PFE and BioNTechs COVID-19 vaccine branded as Comirnaty was the top selling drug in the world with sales reaching a high of $37.8 billion in 2022

Given the burden of this condition and the limitations of current therapies, these results could pave the way for more effective, less invasive treatment strategies for patients living with IIH