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KD is a high-fat, very low-carbohydrate, and moderate-protein dietary approach that induces ketosis, defined by serum ketone body concentrations exceeding 0.5 mmol/L

The KEAP1 protein detects oxidative stress by going through a conformational change that prevents association with NRF2, leading to NRF2 accumulation and translocation to the nucleus, which then induces transcription through antioxidant response elements found in a broad set of genes involved in redox homeostasis and correcting oxidative damage

Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease