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A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

Cancer Lett 372:210218 Myllyl R, Wang C, Heikkinen J, Juffer A, Lampela O, Risteli M, Ruotsalainen H, Salo A, Sipil L (2007) Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3)

There were no significant differences among the three doses of lipoic acid, suggesting that 600 mg/day may be the maximum effective dose (55)

Decongestants (e.g., Pseudoephedrine, Phenylephrine) Used for: Nasal congestion Warning: Can raise blood pressure and heart rate