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In phase II metabolism, which occurs in the intestinal and hepatic cytosol, UDP-UGT and SULT enzymes catalyze the conjugation of glucuronide and sulfate to curcumin and its reduced metabolites (107, 108)
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Ng et al., Journal of Endocrinology found that AOD-9604 stimulates lipolysis and inhibits fat storage without increasing IGF-1 or causing anabolic effects
In adipose models, reduced NNMT activity has been linked with smaller adipocyte size and diminished fat depots, suggesting a potential role for this inhibitor in fat mass modulation under research conditions
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