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1 Phase 3 Success in Obesity The obesity study met its primary endpoint, with up to 10.9% mean weight loss at Week 44 and 11.1% at Week 50 (ad hoc analysis), placing KAI-7535 within the competitive range of leading oral GLP-1 therapies

The 2023 Phase 2 trial reported up to 24.2% mean loss at 48 weeks [2]

Patients with a history of pancreatitis, severe gallbladder disease, or diabetic retinopathy requiring frequent ophthalmologic monitoring need specialized oversight

After removing duplicates and irrelevant studies, a total of 59 articles including 8 animal studies, 2 randomized clinical trials, and 2 in vitro experimental studies were used for the current review