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The overall effects of these alterations are increased emotional hyperactivity (orbitofrontal and basolateral hyperactivity of the amygdala not moderated by the central amygdala equipped with a robust network of GABAergic neurons), memory lability (hippocampal hypotrophy), and cognitive and environmental self-regulation difficulties (mPFC and hippocampal hypotrophy and, consequently, of salience networks, which is based on these areas)

cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive

doi: 10.1016/j.phrs.2023.106788 173 LiuDKouXChenCLiuSLiuYYuWet al

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