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For decades, Aspirin has been the reference pharmacologic agent in colorectal cancer prevention

Randomization is essential to avoid selection bias and ensure that the treatment groups are comparable

The 12 mg arm averaged 28.3% weight loss at 80 weeks

Attempting to lose weight beyond a healthy range can lead to nutrient deficiencies, muscle loss, bone density issues, and other adverse health outcomes, as well as potentially fostering unhealthy relationships with food and body image