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[5] Glutathione depletion has been linked to a number of disease states and groups, including: Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer [6] Glutathione and autoimmune disease An autoimmune disorder occurs when a persons immune system mistakenly attacks their own body

Trials have initiated treatment at a lower dose, with scheduled increases every four weeks to allow for monitoring of tolerability and side effects

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Ethics declarations Sources of support The research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award numbers UH2AR076719, UH3AR076719, U19AR076737, and F32AR081139, and through R01AR070198 and R01AR063705