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FIGURE 6 In animal models developing T2D, a drastic decrease in cardiolipin levels in striated muscle was identified (Figure 6, it is shown that PE improves insulin sensitivity via NOX2 (Figure 7) to promote mitochondrial remodeling resulting in improvement in glucose and fat metabolism ( 2 O 2 levels can activate p38 continuously, inducing melanocytes to premature senescence (dysfunctional) and susceptible to apoptosis ( FIGURE 7 Vitiligo patients have a reduced mitophagy process in epidermal melanocytes (Vainshtein et al., 2015)

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