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Casas R, Dietrich F, Puente-Marin S, et al

Research also suggests that these injections might decrease the risk of dementia and other cognitive impairments, especially in individuals with low B12 levels

10.1371/journal.pone.0182558 114 LiuY.AoX.DingW.PonnusamyM.WuW.HaoX.et al (2018)

So far preferential activation of GIPR activation, combined with less activation of GLP1R and even less activation of GR appear to have produced the most effective combination, as shown by Retatrutide, although whether this mixture is indeed the optimal is still an open question