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GPx4, lipid peroxidation, and cell death: Discoveries, rediscoveries, and open issues

Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine ( Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways

PMCID: PMC12195719

The interplay between oxidative stress, ROS, and male reproductive health is complex