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Mendelian randomisation, a crucial analytical method for evaluating the causality of the association between risk factors and pertinent clinical outcomes, proves invaluable in instances where conducting randomised clinical trials is unfeasible due to ethical concerns and associated expenses [168,169,170]

The list includes cytochrome c oxidase (the terminal electron-transport-chain enzyme), Cu/Zn superoxide dismutase (an antioxidant enzyme), lysyl oxidase (which cross-links collagen and elastin in extracellular matrix), tyrosinase (in melanin synthesis), dopamine beta-hydroxylase (in neurotransmitter synthesis), and others

Med Clin Exp 2004;27:10-3

In human endothelial cells, adenosine causes an upregulation of GPx-1 expression and activity that depends on increased transcript stability rather than alterations in GPx-1 gene transcription (406)