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In response to oxidative stress, NRF2 dissociates from KEAP1, translocates to the nucleus, and activates genes encoding antioxidant enzymes (e.g., superoxide dismutase SOD) and glutathione synthesis enzymes, reducing reactive oxygen species (ROS) and mitigating oxidative damage (21)

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Summary: Some patients taking Wegovy report emotional changes such as mood swings, tearfulness, or low mood, though current UK regulatory evidence does not confirm a direct causal link between GLP-1 receptor agonists and mood disorders