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As an initiating factor, mitochondrial DNA mutations or oxidative damage can disrupt respiratory chain function, leading to energy failure and subsequent organ dysfunction [27]

As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)

Why Lyme Disease Can Be Mistaken for Shingles Lyme disease can affect multiple body systems including the nervous system and autonomic pathways

On palpation at the distal third of the penis, physical examination revealed a nodule measuring about 20 mm in length