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Strober et al

This study has several limitations

Metabolic interaction of folate and related B-vitamins Folate, vitamin B 12 , vitamin B 6 and riboflavin interact by functioning as cofactors within OCM, a network of interrelated cellular pathways essential for numerous biological processes, including the biosynthesis of DNA, amino acid interconversions and methylation reactions (Reference Bailey, Stover and McNulty5)