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The two trials are each expected to enroll 1,840 patients who will be randomly assigned to receive either once-a-day oral semaglutide (tapered to 14 mg) or placebo for 173 weeks

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The majority of Fos-positive cells were in non=TH+ cells (identified by white arrows), with few TH+ cells demonstrated Fos immunoreactivity in response to nicotine (identified by yellow arrows)

Neuropharmacology 62, 18821889