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High-dose Vitamin B12 May Improve ALS Prognosis if Started Early, Study Suggests Written by | Treatment with ultra-high-dose methylcobalamin, the physiologically active form of vitamin B12, may improve the prognosis of patients with amyotrophic lateral sclerosis (ALS) who receive it a year or less after symptom onset, a long-term study of Japanese reports

Briefly, cells were incubated with EdU and counterstained with DAPI, followed by visualization under a fluorescence microscope (Leica)

Ethical approval for the experiment was granted by the Siirt University Local Ethics Committee for Animal Experiments (approval no.: 2025/04/24)

A carboxylic acid directly attached to the 6-position of the benzimidazole proved optimal towards improvements in potency