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This leads to a form of cerebral folate deficiency (CFD) , where the brain has low levels of 5-methyltetrahydrofolate (5-MTHF) , the active folate form crucial for neurotransmitter synthesis, DNA methylation, and myelin formation

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Indeed, it is puzzling why only IGLE neurons detecting intestinal distention induce satiation, while mucosal ending VANs that contain gut peptide receptors and are ideally situated in close proximity to EECs would not be involved in metabolic homeostasis