What to supplement: Methylated B vitamins at moderate doses SAMe supplements under supervision Trimethylglycine (TMG/betaine) to support methylation Supplements that may help regardless of cause: For oxidative stress and glutathione support: NAC (N-acetylcysteine): provides cysteine directly Glycine: another glutathione building block Glutamine: supports gut health and glutathione Vitamin C: antioxidant support Alpha-lipoic acid: regenerates glutathione Selenium: supports glutathione peroxidase The careful approach to supplementation: Step 1: Identify the root cause Test B12, folate, and other relevant markers Assess diet and protein intake Consider genetic testing (MTHFR, CBS, COMT) Evaluate for oxidative stress, inflammation, or toxic burden Step 2: Address foundations first Optimise diet (see foods section) Reduce toxic exposures Support gut health Manage stress Improve sleep Step 3: Start low and go slow Begin with lowest effective doses Introduce one supplement at a time Monitor symptoms carefully Adjust based on response Step 4: Retest and reassess Recheck homocysteine after 2-3 months Monitor symptoms and overall health Adjust supplementation accordingly Work with a knowledgeable practitioner: Low homocysteine is complex and requires individualised treatment

Much of the population is low or deficient in vitamin B12, which can impair your methylation further
Instead, you can see patterns, celebrate milestones with your Journey Card , and create routines that help you succeed in the long run, rather than just relying on willpower
The reported side effects were similar to those of other GLP-1s, including gastrointestinal effects