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Kla suppresses NK cell function by creating cold TMEs, with high Kla scores correlating negatively with TME stromal/immune/estimation scores and positively with tumor purity, indicating promotion of immune desert-type TMEs where reduced NK cell infiltration weakens tumor immune surveillance (118)
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Studies show it can act as both a NO promoter and stabilizer depending on the physiological context, helping maintain optimal blood flow to injured areas
5 BowdenJ.Davey SmithG.BurgessS
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