glp-1 long-term risks Q&A: success of therapies hinges on more than just a prescription Thoughts on long term GLP-1

Radiation alters the surrounding mesenchymal and immune microenvironment, reducing the supply of factors essential for ISC survival and repair, such as R-spondin, epidermal growth factor (EGF) and fibroblast growth factor (FGF) 36

M.ShapiroG.et al (2022)

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Under pathological conditions, phosphatidylethanolamine, derivatives of PUFAs, may undergo oxidation mediated by lipoxygenases, resulting in the formation of lipid peroxides, which can trigger ferroptosis (Uauy et al., 2000)