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The authors found that BPDB-based MOFs exhibited GSH concentration-dependent NO release (Figure 2G), and four molecules of NO can be released from each BPDB molecule provoked by two molecules of GSH (Figure 2H)

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Compared to the antagonist-bound receptor, the extracellular end of TM7 of these two active receptors laterally move ~5 towards TM6 (measured at C of Q302 7.32 ), presenting a unique TM7 conformational change across class A GPCRs solved to date (Fig

There were several limitations of our study