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Who This Guidance Applies To and When to Consult Your Provider Discontinuation planning applies to all individuals using compounded or branded GLP-1 agents (semaglutide, tirzepatide, liraglutide) who are planning pregnancy within the next 612 months
The channel corresponding to anti-Gas antibody is depicted in red
The TRIUMPH-4 safety profile is qualitatively similar to semaglutide and tirzepatide (GI adverse events dominate) but the rate of nausea, vomiting, and diarrhea is higher than previously seen in the class, and dropout at 12 mg is higher than at 9 mg
Like other GLP-1 products, the most common adverse event was gastrointestinal side effects (nausea, vomiting, diarrhea), which tended to decrease over time
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