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Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)

Effect of a novel long-acting GLP-1/GIP/glucagon triple agonist (HM15211) in a NASH and fibrosis animal model

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Severe effects requiring immediate emergency care include severe abdominal pain, yellowing of skin or eyes, swelling of the face or throat, difficulty breathing, fainting, vision changes, or very rapid heartbeat