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In reference to the nature of ROS behavior as a double-edged sword, even though several studies have documented the benefits of antioxidant drugs for cancer therapies, none has been supported by solid trials performed on a large scale 153,154

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( Reference Lawler, Barnes and Wu 34 ) demonstrated a direct doseresponse relationship of creatine concentration with superoxide anion (O 2 ), peroxynitrite (OONO ) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as determined by the rate of renewal of the ABTS + radical, and concluded that creatine has a significant role as an antioxidant