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Despite consuming food equivalent to half of their body weight, these lizards can effectively regulate blood glucose levels due to the presence of exendin-4.[35] Exendin-4 shares structural similarity with GLP-1, binds to its receptor with comparable affinity, but has a longer half-life than GLP-1.[36] The discovery led to the development of exenatide, the first GLP-1 analog for type 2 diabetes,[37] followed by subsequent analogs with improved pharmacokinetics

For example, phenobarbital, pregabalin, primidone and topiramate