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This article examines how the two interact theoretically, what the current evidence says, and the key safety considerations you should discuss with a qualified healthcare professional

Proteotoxicity and cardiac dysfunction

Its worth noting that these positive effects were only seen in patients taking long-acting GLP-1 receptor agonists (more commonly prescribed) and not in those using short-acting agents

Collectively, these findings suggest that FGF21 may mediate some of the beneficial effects of exercise on atherosclerosis, particularly through the PI3K/AKT signaling pathway and anti-apoptotic mechanisms