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Top-line outcomes at the 48-week primary endpoint, by dose: Notable Phase 2 finding particularly relevant to the 10mg vial: the 1mg/week cohort still produced 8.7% mean weight loss over 48 weeks, clinically meaningful activity even at sub-therapeutic doses relative to the 12mg maximum

An unknown fraction of these lesions are treated by consensus before excision (cryotherapy, fluorouracil use, etc.) resulting in distorted morphological features such as hyper or hypo pigmentation and scarring of the lesion and therefore were omitted from this study due to the lack of criteria of excision (Drno et al

Publication bias was evaluated using funnel plots for RCTs that provided data on the primary outcome, as shown in Supplemental Fig