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10.1007/s00401-015-1479-z 172 StebbinsM

81%) than in female patients (24 of 43

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When SARS-CoV-2 infects the cells, the virus binds to ACE2 using its S1 subunit, permitting the S2 subunit to undergo cleavage by the host transmembrane serine protease 2 (TMPRSS2), leading to fusion of the viral envelope and cell membrane, and subsequent internalisation of the virus, as well as the bound ACE2, by endocytosis 5, 6