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Sparse clinical evidence versus real-world experience In a review of the evidence posted ahead of the meeting, they repeatedly note the data comes primarily from preclinical work involving animals and is quite limited for humans

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

The interaction of Cu(II) and glycyl-L-histidyl-L-lysine: a copper-binding peptide present in human plasma

Mice were administered a single topical drop (2.5 L) of NAC (18.35 mg/mL) or NACET (21.5 mg/mL) gel-forming drops, or gel-forming vehicle alone bilaterally daily starting from when their eyes opened (P13-15) through P65