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In Phase 3 clinical trials, it helped adults without diabetes lose up to 22.7% of their body weight over 68 weeks, and adults with type 2 diabetes lose up to 15.7%

[16] [23] Detecting a small increase in risk would require extremely large populations and prolonged follow-up periods

Structurally, retatrutide is a 39-amino acid peptide conjugated to a C20 fatty diacid moiety, which confers an extended pharmacokinetic half-life suitable for once-weekly dosing in clinical research settings

However, the absence of endorsement from regulatory bodies raises significant concerns regarding the safety and efficacy of this practice