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The authors framed the study around the hypothesis that simultaneous activation of GIP, GLP-1, and GCG receptors could produce different neurobiological effects compared with previously studied single- or dual-receptor agonists

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An expanded composite endpoint of MACE plus unstable angina resulting in hospitalization or HF resulting in hospitalization occurred in 5.2% of the patients receiving subcutaneous semaglutide and in 6.3% of those receiving placebo (HR 0.82