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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38

Studies have also shown that increased intake of flavonoids and polyphenols in populations above 65 years reduces the relative risk of neurodegenerative diseases [183]

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