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10.1213/XAA.0000000000001751 [DOI] [PubMed] [Google Scholar] 35.Sherwin M, Hamburger J, Katz D, DeMaria S Jr (2023) Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide

Losing muscle while losing fat means the metabolism slows more than it should, making weight maintenance harder after the medication is discontinued

The half-life of the active ingredient, the absorption pathway, and the bioavailability all play roles in determining how often you need to dose