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IDF Diabetes atlas | tenth edition

This is an area where few other options exist, and those that do, such as Neurontin, Lyrica, or opiates are highly sedating

DPP-4 inhibitors [37], which elevate incretin hormone levels to maintain glucose homeostasis, have yielded mixed findings regarding their association with intestinal obstruction: a smaller study of 40,615 patients indicated a potential risk [15], while a larger cohort study of 190,321 patients across three countries found no increased risk [16]