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For healthcare systems and policymakers, the evidence supports cautious optimism tempered by realistic acknowledgment of current limitations and the need for comprehensive approaches that address pharmacological efficacy, access, sustainability, and equity concerns

Conversely, some case reports for exenatide 181 and semaglutide 182 described onset or relapse of depressive symptoms, which resolved when the GLP-1RAs were stopped 181,182 and recurred on medication rechallenge 181

One of the most reported problems is diarrhea